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Title: Comparative neuroanatomy of angiotensin II receptor localization in the mammalian hypothalamus.
Authors: Allen, A M;McKinley, M J;Mendelsohn, Frederick AO
Affiliation: University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Feb-1988
Citation: Clinical and Experimental Pharmacology & Physiology; 15(2): 137-45
Abstract: 1. The distribution of angiotensin II (AII) receptor binding sites in the hypothalamus of rat, rabbit, sheep and human was determined by in vitro autoradiography using 125I-[Sar1,Ile8]-AII as radioligand. 2. High receptor binding levels were observed in the continuum of tissue comprising the anterior wall of the third ventricle, including the subfornical organ, the median pre-optic nucleus and the organum vasculosum of the lamina terminalis. 3. High levels of binding sites were also found in the paraventricular and supra-optic nuclei, the median eminence and the arcuate nucleus. 4. These findings demonstrate sites in the hypothalamus of rat, rabbit, sheep and human where AII could exert its known actions on fluid and electrolyte balance, pituitary hormone release and cardiovascular function.
Internal ID Number: 3271605
Type: Journal Article
Subjects: Aged
Hypothalamus.anatomy & histology.metabolism
In Vitro Techniques
Iodine Radioisotopes.diagnostic use
Rats, Inbred Strains
Receptors, Angiotensin.drug effects.metabolism
Species Specificity
Appears in Collections:Journal articles

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