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Title: Impairment of inhibitory cardiopulmonary vagal reflexes in spontaneously hypertensive rats.
Authors: Verberne, Anthony J M;Young, N A;Louis, William J
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Australia
Issue Date: 1-Jun-1988
Citation: Journal of the Autonomic Nervous System; 23(1): 63-8
Abstract: The activity of cardiopulmonary reflexes elicited by 5-hydroxytryptamine (5-HT) and phenyldiguanide (PDG) has been examined in anaesthetised 5- and 12-week-old spontaneously hypertensive (SHR) rats. Intravenous injections of 5-HT or PDG elicited dose-dependent bradycardic and hypotensive responses. In the 5-week-old SHR rats the bradycardic and hypotensive responses to 5-HT were smaller than those measured in WKY rats. At 12 weeks, the SHR rats were less sensitive to the bradycardic actions of 5-HT, as well as PDG, although the reduction in cardiopulmonary reflex sensitivity was less pronounced than that observed in the 5-week-old SHR rats. These findings suggest that cardiopulmonary reflexes are impaired in the SHR rat although some amelioration of this phenomenon may occur as hypertension develops.
Internal ID Number: 3171087
Type: Journal Article
Subjects: Animals
Blood Pressure.drug effects
Heart Rate.drug effects
Rats, Inbred SHR.physiology
Rats, Inbred Strains.physiology
Rats, Inbred WKY.physiology
Vagus Nerve.physiology
Appears in Collections:Journal articles

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