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|Title:||Impairment of inhibitory cardiopulmonary vagal reflexes in spontaneously hypertensive rats.|
|Authors:||Verberne, Anthony J M;Young, N A;Louis, William J|
|Affiliation:||University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Australia|
|Citation:||Journal of the Autonomic Nervous System; 23(1): 63-8|
|Abstract:||The activity of cardiopulmonary reflexes elicited by 5-hydroxytryptamine (5-HT) and phenyldiguanide (PDG) has been examined in anaesthetised 5- and 12-week-old spontaneously hypertensive (SHR) rats. Intravenous injections of 5-HT or PDG elicited dose-dependent bradycardic and hypotensive responses. In the 5-week-old SHR rats the bradycardic and hypotensive responses to 5-HT were smaller than those measured in WKY rats. At 12 weeks, the SHR rats were less sensitive to the bradycardic actions of 5-HT, as well as PDG, although the reduction in cardiopulmonary reflex sensitivity was less pronounced than that observed in the 5-week-old SHR rats. These findings suggest that cardiopulmonary reflexes are impaired in the SHR rat although some amelioration of this phenomenon may occur as hypertension develops.|
|Internal ID Number:||3171087|
Blood Pressure.drug effects
Heart Rate.drug effects
Rats, Inbred SHR.physiology
Rats, Inbred Strains.physiology
Rats, Inbred WKY.physiology
|Appears in Collections:||Journal articles|
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