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|Title:||Attenuated renal response to atrial natriuretic peptide infusion in rats with heart failure.|
|Authors:||Kohzuki, M;Hodsman, G P;Harrison, R W;Johnston, Colin I|
|Affiliation:||University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia|
|Citation:||Clinical and Experimental Pharmacology & Physiology; 15(4): 323-6|
|Abstract:||1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.|
|Internal ID Number:||2978744|
Atrial Natriuretic Factor.administration & dosage.pharmacology
Blood Pressure.drug effects
Dose-Response Relationship, Drug
Rats, Inbred Strains
|Appears in Collections:||Journal articles|
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