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|Title:||Progression of proteinuria in type 1 and type 2 diabetes.|
|Authors:||Cooper, Mark E;Frauman, Albert G;O'Brien, R C;Seeman, Ego;Murray, R M;Jerums, George|
|Affiliation:||Endocrine Unit, Austin Hospital, University of Melbourne, Australia.|
|Citation:||Diabetic Medicine : A Journal of the British Diabetic Association; 5(4): 361-8|
|Abstract:||A longitudinal study evaluating the time course of the transition from normal to microalbuminuria, and then on to macroalbuminuria, was made over a mean period of 7 years in a cohort of 52 patients with Type 1 diabetes and 61 patients with Type 2 diabetes. Transient episodes of micro- and macroalbuminuria were often observed before the ultimate development of persistent Albustix-positive proteinuria. The transition from normal to microalbuminuria and from micro- to macroalbuminuria was characterized by rises in renal albumin clearance accompanied by lesser rises in total proteinuria. Seven patients with Type 1 and 12 with Type 2 diabetes showed evidence of progression, the interval for the transition from normal to macroalbuminuria varying from 3 to 5 years. In Type 1 diabetic patients, the development of micro- and macroalbuminuria was associated with a decline in renal function and a rise in systolic blood pressure without a significant change in blood glucose control. In Type 2 diabetic patients, the development of microalbuminuria was associated with a small decline in renal function but no change in blood pressure or blood glucose control. It is concluded that the transition from normal to micro- and on to macroalbuminuria may be more rapid then previously reported and varies considerably among individuals.|
|Internal ID Number:||2968887|
Diabetes Mellitus, Type 1.physiopathology.urine
Diabetes Mellitus, Type 2.physiopathology.urine
Hemoglobin A, Glycosylated.analysis
|Appears in Collections:||Journal articles|
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