Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12907
Title: Biotransformation studies of di-acid angiotensin converting enzyme inhibitors.
Authors: Drummer, Olaf H;Kourtis, S
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria (Australia).
Issue Date: 1-Nov-1987
Citation: Arzneimittel-forschung; 37(11): 1225-8
Abstract: The biotransformation of di-acid inhibitors of angiotensin converting enzyme was studied in the urine of rats using gas chromatography/mass spectrometry. It was found that after oral administration (10 mg/kg) of enalapril significant amounts (9.2%) of a hydrolytic metabolite of enalaprilat were excreted in urine which was identified as 2-N-alanyl-4-phenylbutanoic acid. This metabolite was present only in trace concentrations in urine after intravenous administration. This pathway was not present, however, with either ramipril or perindopril suggesting that the amide bond in these newer inhibitors is more resistant to hydrolysis than for enalapril. Glucuronidase hydrolysis of urine obtained from rats dosed with either enalapril, ramipril or perindopril indicated the absence of glucuronidate conjugates of these inhibitors in rat urine.
Internal ID Number: 2964241
URI: http://ahro.austin.org.au/austinjspui/handle/1/12907
URL: http://www.ncbi.nlm.nih.gov/pubmed/2964241
Type: Journal Article
Subjects: Angiotensin-Converting Enzyme Inhibitors.metabolism.urine
Animals
Bicyclo Compounds.metabolism
Biotransformation
Female
Gas Chromatography-Mass Spectrometry
Glucuronates.metabolism
Hydrolysis
Indoles.metabolism
Male
Perindopril
Ramipril
Rats
Rats, Inbred Strains
Appears in Collections:Journal articles

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