Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12904
Title: Responses of vasoactive hormones in congestive cardiac failure.
Authors: Johnston, Colin I;Arnolda, L F;Tsunoda, K;Phillips, P A;Hodsman, G P
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Aug-1987
Citation: Canadian Journal of Physiology and Pharmacology; 65(8): 1706-11
Abstract: Congestive cardiac failure causes activation of various neurohumoral responses that increase total peripheral resistance and promote salt and water retention. These effects increase blood pressure and organ perfusion in the short term, but ultimately cause further cardiac decompensation by increasing ventricular afterload and cardiac work. The role of the renin-angiotensin-aldosterone system and the catecholamines is partially understood, and blockade of these systems as a treatment of heart failure is now established. The role of vasopressin in heart failure is more controversial, but there is now compelling evidence that vasopressin may have important vasoconstrictor actions in addition to its fluid retaining properties. Atrial natriuretic factor is a newly described cardiac hormone released from the atrium. Atrial natriuretic factor causes natriuresis, diuresis, vasodilatation, suppression of thirst, and suppression of both renin and aldosterone. These actions largely counteract the effects of the renin-angiotensin system and vasopressin. Plasma atrial natriuretic factor has been reported to be markedly elevated in human and experimental heart failure, and may act to limit the neurohumoral response to reduced cardiac output. This review summarizes our understanding of the vasoactive hormones and reports experimental evidence supporting a pathophysiological role for vasopressin and atrial natriuretic factor in congestive cardiac failure.
Internal ID Number: 2961425
URI: http://ahro.austin.org.au/austinjspui/handle/1/12904
URL: http://www.ncbi.nlm.nih.gov/pubmed/2961425
Type: Journal Article
Subjects: Animals
Atrial Natriuretic Factor.physiology
Heart Failure.physiopathology
Humans
Renin-Angiotensin System
Sympathetic Nervous System.physiopathology
Vasopressins.physiology
Appears in Collections:Journal articles

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