Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12901
Title: Atrial natriuretic factor in chronic renal failure: studies in man and the rat.
Authors: Hodsman, G P;Jackson, B;Debrevi, L M;Ogawa, K;Johnston, Colin I
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria.
Issue Date: 1-Mar-1987
Citation: Clinical and Experimental Pharmacology & Physiology; 14(3): 247-51
Abstract: 1. Plasma concentration and atrial content of atrial natriuretic factor (ANF) were measured in rats with chronic renal failure induced by subtotal nephrectomy. 2. Plasma ANF was higher, and atrial ANF content lower in rats with renal failure when compared with sham-operated controls. 3. Plasma renin activity (PRA) and ANF were elevated at 1 week following subtotal nephrectomy. After 1 month plasma ANF had risen further, but PRA was suppressed to below control values. 4. Plasma ANF was also measured in six patients with chronic renal failure undergoing routine haemodialysis. 5. Elevated plasma ANF levels in patients with renal failure were lowered by haemodialysis, although extraction of ANF across the dialysis membrane was negligible. 6. Secretion of ANF is increased in chronic renal failure in man and the rat, possibly mediated by increased intravascular volume.
Internal ID Number: 2959420
URI: http://ahro.austin.org.au/austinjspui/handle/1/12901
URL: http://www.ncbi.nlm.nih.gov/pubmed/2959420
Type: Journal Article
Subjects: Animals
Atrial Natriuretic Factor.blood
Body Weight
Creatinine.blood
Hematocrit
Humans
Kidney Failure, Chronic.metabolism
Male
Nephrectomy
Rats
Rats, Inbred Strains
Renal Dialysis
Renin.blood
Renin-Angiotensin System
Appears in Collections:Journal articles

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