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|Title:||Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease.|
|Authors:||Norman, Trevor R;Chiu, E;James, R H;Gregory, M S|
|Affiliation:||Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.|
|Citation:||European Journal of Clinical Pharmacology; 32(6): 583-6|
|Abstract:||The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following drug administration with a mean value of 0.92 micrograms/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h.|
|Internal ID Number:||2958291|
|Appears in Collections:||Journal articles|
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