Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12881
Title: Nature of the gastric acid-gastrin feedback loop in the fetal sheep.
Authors: Shulkes, Arthur;Chick, P;Hardy, Kenneth John
Affiliation: Department of Surgery, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Jun-1987
Citation: Clinical and Experimental Pharmacology & Physiology; 14(6): 503-12
Abstract: 1. The neonates of sheep and other species have a decreased gastric acid secretion but an elevated plasma gastrin concentration. 2. Since low gastric acid secretion is a stimulus for gastrin release in mature animals the present study examined whether the relative hypochlorhydria in the sheep fetus was sustaining the hypergastrinaemia. 3. Fetal plasma gastrin was measured following fetal gastric acidification (pentagastrin infusion) and gastric neutralization (parietal cell blockade with the proton pump inhibitor omeprazole) in chronically cannulated fetal sheep from 101 days until term (145 days). 4. Acutely raising gastric pH with omeprazole increased plasma gastrin in the mature sheep. However, in the fetus increasing the pH with omeprazole or decreasing pH with pentagastrin had no effect on fetal plasma gastrin. This was true for fetuses from all age groups. 5. The results indicate that the gastric acid-gastrin feedback loop is not functional in the fetus and that the hypergastrinaemia at birth is therefore not the result of the relative hypochlorhydria. 6. The time after birth when the gastric acid-gastrin feedback loop matures remains to be determined.
Internal ID Number: 2890457
URI: http://ahro.austin.org.au/austinjspui/handle/1/12881
URL: http://www.ncbi.nlm.nih.gov/pubmed/2890457
Type: Journal Article
Subjects: Animals
Feedback
Female
Fetus.physiology
Gastric Acid.secretion
Gastric Acidity Determination
Gastrins.blood
Omeprazole.pharmacology
Pentagastrin.pharmacology
Sheep
Somatostatin.pharmacology
Appears in Collections:Journal articles

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