Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12876
Title: Effects of perindopril on angiotensin converting enzyme in tissues of the rat.
Authors: Jackson, B;Cubela, R B;Johnston, Colin I
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Dec-1988
Citation: Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension; 6(3): S51-4
Abstract: Perindopril, an orally active angiotensin converting enzyme (ACE) inhibitor, was fed by gavage to male Sprague-Dawley rats. The effect on tissue ACE was measured ex vivo by quantitation of binding of the specific radioligand 125I-3511A to ACE in tissue homogenates. In an acute time-course study perindopril (1, 4 or 8 mg/kg) inhibited plasma ACE activity by more than 90% in 1 h but no inhibition remained after 24 h. Kidney ACE was affected to a similar degree and followed a similar time-course of inhibition to plasma ACE. In contrast, ACE was inhibited to a lesser degree in lung and aorta homogenates, with maximum effect 4-8 h postgavage, and with inhibition persisting 48 h following the dose. In testis homogenates, ACE remained unaltered following the administration of perindopril at all three doses. Therefore we conclude that plasma ACE inhibition does not parallel tissue effects, and that drug penetration into the testis appears to be limited.
Internal ID Number: 2852236
URI: http://ahro.austin.org.au/austinjspui/handle/1/12876
URL: http://www.ncbi.nlm.nih.gov/pubmed/2852236
Type: Journal Article
Subjects: Angiotensin-Converting Enzyme Inhibitors.pharmacology
Animals
Aorta.enzymology
Indoles.pharmacokinetics.pharmacology
Kidney.enzymology
Lung.enzymology
Male
Peptidyl-Dipeptidase A.blood.metabolism
Perindopril
Rats
Rats, Inbred Strains
Testis.enzymology
Appears in Collections:Journal articles

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