Please use this identifier to cite or link to this item:
|Title:||Quantitative conformational analyses predict distinct receptor sites for PCP-like and sigma drugs.|
|Authors:||Manallack, D T;Beart, P M|
|Affiliation:||University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia.|
|Citation:||European Journal of Pharmacology; 144(2): 231-5|
|Abstract:||Computer-assisted molecular modelling techniques have been employed to develop receptor models for the phencyclidine (PCP) and sigma binding sites. The models differ in the position of the nitrogen atom, direction of the nitrogen-lone pair vector and in the location and nature of secondary binding groups. This study predicts the existence of distinct receptors for sigma and PCP ligands, and our receptor models can be used to design and predict the activity of drugs with PCP and/or sigma activity.|
|Internal ID Number:||2830125|
In Vitro Techniques
Phenazocine.analogs & derivatives.metabolism
Rats, Inbred Strains
|Appears in Collections:||Journal articles|
Files in This Item:
There are no files associated with this item.
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.