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Title: Quantitative conformational analyses predict distinct receptor sites for PCP-like and sigma drugs.
Authors: Manallack, D T;Beart, P M
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Dec-1987
Citation: European Journal of Pharmacology; 144(2): 231-5
Abstract: Computer-assisted molecular modelling techniques have been employed to develop receptor models for the phencyclidine (PCP) and sigma binding sites. The models differ in the position of the nitrogen atom, direction of the nitrogen-lone pair vector and in the location and nature of secondary binding groups. This study predicts the existence of distinct receptors for sigma and PCP ligands, and our receptor models can be used to design and predict the activity of drugs with PCP and/or sigma activity.
Internal ID Number: 2830125
Type: Journal Article
Subjects: Animals
Binding Sites
Computer Graphics
Dizocilpine Maleate
In Vitro Techniques
Molecular Conformation
Phenazocine.analogs & derivatives.metabolism
Rats, Inbred Strains
Receptors, Neurotransmitter.metabolism
Receptors, Opioid.metabolism
Receptors, Phencyclidine
Receptors, sigma
Appears in Collections:Journal articles

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