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Title: | Quantitative conformational analyses predict distinct receptor sites for PCP-like and sigma drugs. | Austin Authors: | Manallack, D T;Beart, P M | Affiliation: | University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Dec-1987 | Publication information: | European Journal of Pharmacology; 144(2): 231-5 | Abstract: | Computer-assisted molecular modelling techniques have been employed to develop receptor models for the phencyclidine (PCP) and sigma binding sites. The models differ in the position of the nitrogen atom, direction of the nitrogen-lone pair vector and in the location and nature of secondary binding groups. This study predicts the existence of distinct receptors for sigma and PCP ligands, and our receptor models can be used to design and predict the activity of drugs with PCP and/or sigma activity. | Gov't Doc #: | 2830125 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12855 | Journal: | European Journal of Pharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/2830125 | Type: | Journal Article | Subjects: | Animals Binding Sites Brain.metabolism Computer Graphics Dibenzocycloheptenes.metabolism Dizocilpine Maleate In Vitro Techniques Isoquinolines.metabolism Male Molecular Conformation Phenazocine.analogs & derivatives.metabolism Phencyclidine.metabolism Rats Rats, Inbred Strains Receptors, Neurotransmitter.metabolism Receptors, Opioid.metabolism Receptors, Phencyclidine Receptors, sigma |
Appears in Collections: | Journal articles |
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