Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12850
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dc.contributor.authorChristie, M Jen
dc.contributor.authorSummers, R Jen
dc.contributor.authorStephenson, J Aen
dc.contributor.authorCook, C Jen
dc.contributor.authorBeart, P Men
dc.date.accessioned2015-05-16T02:35:51Z
dc.date.available2015-05-16T02:35:51Z
dc.date.issued1987-08-01en
dc.identifier.citationNeuroscience; 22(2): 425-39en
dc.identifier.govdoc2823173en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12850en
dc.description.abstractAfferents to the nucleus accumbens septi utilizing glutamate or aspartate have been investigated in the rat by autoradiography following injection and retrograde transport of D[3H]aspartate. Parallel experiments with the intra-accumbal injection of [3H]GABA were employed to establish the transmitter-selective nature of the retrograde labelling found with D[3H]aspartate. The topography of cortical and thalamic perikarya labelled by D[3H]aspartate was extremely precise. D[3H]Aspartate labelled perikarya were found in layer V of agranular insular cortex; bilaterally within prelimbic and infralimbic subareas perikarya, but predominantly ipsilaterally. Ipsilateral labelling was observed in dorsal, ventral and posterior agranular insular cortices, and in perirhinal cortex. Injections into ventral accumbens labelled perikarya in ipsilateral entorhinal cortex, while infusion of D[3H]aspartate into anterior caudate-putamen resulted in labelling of perikarya in ipsilateral cingulate and lateral precentral cortices. Following infusion of D[3H]aspartate, ipsilateral midline thalamic nuclei contained the highest density of labelled perikarya; infusions centred on nucleus accumbens resulted in heavy retrograde labelling of the parataenial nucleus, but labelling was sparse from a lateral site and not observed after injection into anterior caudate-putamen. Less prominent labelling of perikarya was seen in other thalamic nuclei (mediodorsal, central medial, rhomboid, reuniens and centrolateral), mostly near the midline. Perikaryal labelling was also found in the ipsilateral amygdaloid complex, particularly in basolateral and lateral nuclei. Only weak labelling resulted in ventral subiculum. Numerous labelled cells were present bilaterally in anterior olfactory nucleus, although perikarya were more prominent ipsilaterally. Labelled perikarya were not consistently observed in other regions (ventral tegmental area, medial substantia nigra, raphe nuclei and locus coeruleus) known to innervate nucleus accumbens. Presumptive anterograde labelling was detected in ventral pallidum/substantia innominata, ventral tegmental area and medial substantia nigra. [3H]GABA was generally not retrogradely transported to the same regions labelled by D[3H]aspartate; an exception being the anterior olfactory nucleus, where large numbers of labelled perikarya were found. [3H]GABA failed to label perikarya in thalamus and amygdala, and a topographic distribution of label was absent in neocortex.(ABSTRACT TRUNCATED AT 400 WORDS)en
dc.language.isoenen
dc.subject.otherAmino Acids.metabolismen
dc.subject.otherAmygdala.metabolism.physiologyen
dc.subject.otherAnimalsen
dc.subject.otherAspartic Acid.diagnostic useen
dc.subject.otherAutoradiographyen
dc.subject.otherCerebral Cortex.metabolism.physiologyen
dc.subject.otherMaleen
dc.subject.otherNucleus Accumbens.metabolism.physiologyen
dc.subject.otherOlfactory Pathways.metabolism.physiologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherSeptal Nuclei.physiologyen
dc.subject.otherSynaptic Transmissionen
dc.subject.otherThalamus.metabolism.physiologyen
dc.subject.otherTritium.diagnostic useen
dc.subject.othergamma-Aminobutyric Acid.diagnostic useen
dc.titleExcitatory amino acid projections to the nucleus accumbens septi in the rat: a retrograde transport study utilizing D[3H]aspartate and [3H]GABA.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroscienceen
dc.identifier.affiliationUniversity of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages425-39en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2823173en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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