Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12847
Title: The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat.
Authors: Verberne, Anthony J M;Costa, M;Lewis, S J;Louis, William J;Beart, P M
Affiliation: University of Melbourne, Department of Medicine, Austin, Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Aug-1987
Citation: Neuropharmacology; 26(8): 1243-6
Abstract: The effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5-16 microgram/kg) produced pronounced dose-dependent hypotensive and bradycardic responses which were attenuated by MK-801 (1 mg/kg, i.v.) but not by saline. The data suggests that activation of the Bezold-Jarisch reflex by 5-HT involves a glutamatergic synapse presumably located within the brainstem vagal reflex arc.
Internal ID Number: 2821444
URI: http://ahro.austin.org.au/austinjspui/handle/1/12847
URL: http://www.ncbi.nlm.nih.gov/pubmed/2821444
Type: Journal Article
Subjects: Anesthesia
Animals
Blood Pressure.drug effects
Cardiovascular Physiological Phenomena
Dibenzocycloheptenes.pharmacology
Dizocilpine Maleate
Heart Rate.drug effects
Male
Rats
Rats, Inbred WKY
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter.metabolism
Reflex.drug effects
Sensory Receptor Cells.drug effects
Serotonin.pharmacology
Urethane
Appears in Collections:Journal articles

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