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|Title:||The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat.|
|Authors:||Verberne, Anthony J M;Costa, M;Lewis, S J;Louis, William J;Beart, P M|
|Affiliation:||University of Melbourne, Department of Medicine, Austin, Hospital, Heidelberg, Victoria, Australia.|
|Citation:||Neuropharmacology; 26(8): 1243-6|
|Abstract:||The effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5-16 microgram/kg) produced pronounced dose-dependent hypotensive and bradycardic responses which were attenuated by MK-801 (1 mg/kg, i.v.) but not by saline. The data suggests that activation of the Bezold-Jarisch reflex by 5-HT involves a glutamatergic synapse presumably located within the brainstem vagal reflex arc.|
|Internal ID Number:||2821444|
Blood Pressure.drug effects
Cardiovascular Physiological Phenomena
Heart Rate.drug effects
Rats, Inbred WKY
Sensory Receptor Cells.drug effects
|Appears in Collections:||Journal articles|
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