Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12839
Title: Acute intracerebroventricular injections of the mast cell degranulator compound 48/80 and behavior in rats.
Authors: Lewis, S J;Quinn, M J;Fennessy, M R;Jarrott, B
Affiliation: Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-May-1989
Citation: Pharmacology, Biochemistry, and Behavior; 33(1): 75-9
Abstract: The intracerebroventricular (ICV) injection of the mast cell degranulator Compound 48/80 (2.5-2.0 micrograms/kg) produced a marked behavioral syndrome in normotensive rats. The behaviors included head and body shakes, paw tremor, excessive grooming, unusual posture and gait, mild diarrhoea, piloerection, extreme agitation and irritability to touch, and a later phase of sedation. The highest doses (15 and 20 micrograms/kg) also produced catalepsy and episodes of "barrel rolling" (continuous rolling of 1-8 turns around the longitudinal axis). These behaviors were observed for approximately 15-30 min although the sedation and catalepsy were maintained for 90-120 min. A second ICV injection of the 10 micrograms/kg dose of Compound 48/80 given 2 hr after an initial injection of this dose, produced a much reduced response and the numbers of head and body shakes, and episodes of paw tremor and grooming were between 20-30% of those produced by the first injection. The reduced effect of the second injection indicates that the behavioral effects of Compound 48/80 may arise from the acute degranulation of mast cells rather than direct effects on neuronal populations or the cerebral vasculature.
Internal ID Number: 2780792
URI: http://ahro.austin.org.au/austinjspui/handle/1/12839
URL: http://www.ncbi.nlm.nih.gov/pubmed/2780792
Type: Journal Article
Subjects: Animals
Behavior, Animal.drug effects
Cytoplasmic Granules.drug effects
Female
Injections, Intraventricular
Mast Cells.drug effects
Rats
Rats, Inbred Strains
Time Factors
p-Methoxy-N-methylphenethylamine.administration & dosage.pharmacology
Appears in Collections:Journal articles

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