Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12831
Title: The concentration of neuropeptide Y immunoreactivity falls with age selectively in microdissected regions of the ventrolateral medulla of spontaneously hypertensive and normotensive Wistar-Kyoto rats.
Authors: Maccarrone, C;Conway, Elizabeth L;Jarrott, B
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-May-1989
Citation: Journal of Hypertension; 7(5): 417-22
Abstract: The concentrations of neuropeptide Y immunoreactivity were measured in microdissected regions enriched in noradrenergic (A1, A2, A6) and adrenergic (C1, C2, C3) nuclei of the brainstem, and in the nucleus of the spinal tract of the trigeminal nerve (Sp5C) of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats at 8, 18 and 31 weeks of age. The aim of this study was to compare the manner in which changes in neuropeptide Y immunoreactivity levels related to increases in blood pressure with ageing in each rat strain. The concentration of neuropeptide Y immunoreactivity in the A1 nucleus progressively fell with increasing age in both SHR and WKY. In contrast, the levels of neuropeptide Y immunoreactivity in the C1 region fell at 18 weeks of age but did not fall further by 31 weeks. No significant age-related changes occurred in the concentrations of neuropeptide Y immunoreactivity in the A2, C2, A6 and Sp5C nucleus. The levels of neuropeptide Y immunoreactivity in the C3 region were below assay sensitivity. The neurochemical changes that occur in the A1 nucleus are consistent with the increase in blood pressure observed with ageing in both rat strains. However, this observation alone does not account for the elevated blood pressure measured in the SHR strain.
Internal ID Number: 2768828
URI: http://ahro.austin.org.au/austinjspui/handle/1/12831
URL: http://www.ncbi.nlm.nih.gov/pubmed/2768828
Type: Journal Article
Subjects: Aging.metabolism
Animals
Blood Pressure
Brain Mapping
Brain Stem.analysis.anatomy & histology
Male
Medulla Oblongata.analysis.anatomy & histology
Neuropeptide Y.analysis
Rats
Rats, Inbred SHR.metabolism
Rats, Inbred Strains.metabolism
Rats, Inbred WKY.metabolism
Appears in Collections:Journal articles

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