Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12825
Title: The titre of anti-centromere antibodies: its relationship to Raynaud's phenomenon and vascular occlusion.
Authors: Buchanan, Russell R C;Riglar, A G
Affiliation: Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Jun-1989
Citation: British Journal of Rheumatology; 28(3): 221-6
Abstract: A retrospective survey of all patients with positive anti-centromere antibody (ACA) determinations over a 5-year period was undertaken. Of the 52 patients identified, seven denied symptoms of Raynaud's phenomenon, all of whom had antibody titres of 2560 or less. One of these showed a 16-fold increase in titre with the onset of Raynaud's, 12 years after original presentation. The remaining 45 patients experienced Raynaud's on cold exposure. Within this group, seven developed thrombotic vascular disease, five of whom were associated with an ACA titre of 20,480 or above. Another two with similar high ACA titres developed hyper-reninaemic hypertension, suggesting disease of the renal vasculature and associated ischaemia. Where it was possible to ascertain, seven of eight with high titre ACA developed sclerodactyly. In contrast, this was not seen in those with low titre ACA of 2560 or less and who also denied Raynaud's phenomenon.
Internal ID Number: 2730983
URI: http://ahro.austin.org.au/austinjspui/handle/1/12825
URL: http://www.ncbi.nlm.nih.gov/pubmed/2730983
Type: Journal Article
Subjects: Adult
Aged
Antibodies.analysis
Centromere.immunology
Chromosomes.immunology
Fingers
Humans
Middle Aged
Raynaud Disease.immunology
Retrospective Studies
Scleroderma, Localized.immunology
Thrombosis.immunology
Appears in Collections:Journal articles

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