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Title: Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes.
Authors: Nayler, W G;Liu, J J;Panagiotopoulos, Sianna;Casley, David J
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-1989
Citation: British Journal of Pharmacology; 97(4): 993-5
Abstract: The effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin [( 125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg-1), the density of [125I]ET binding sites was reduced (P less than 0.01) without changes in affinity or selectivity.
Internal ID Number: 2676060
ORCID: 0000-0002-0845-0001
Type: Journal Article
Subjects: Animals
Binding Sites
Diabetes Mellitus, Experimental.metabolism
In Vitro Techniques
Iodine Radioisotopes.diagnostic use
Rats, Inbred Strains
Appears in Collections:Journal articles

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