Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12781
Title: Programmed cell death-1 inhibition in lymphoma.
Authors: Hawkes, Eliza A;Grigg, Andrew P;Chong, Geoffrey
Affiliation: Department of Medical Oncology and Clinical Haematology, Olivia Newton John Cancer and Wellness Centre, Austin Hospital, Melbourne, VIC, Australia; Department of Medical Oncology, Eastern Health, Melbourne, VIC Australia; Monash University, Melbourne, VIC, Australia. Electronic address: eliza.hawkes@onjcri.org.au.
Department of Medical Oncology and Clinical Haematology, Olivia Newton John Cancer and Wellness Centre, Austin Hospital, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia.
Department of Medical Oncology and Clinical Haematology, Olivia Newton John Cancer and Wellness Centre, Austin Hospital, Melbourne, VIC, Australia; Department of Oncology, Northern Hospital, Melbourne, VIC, Australia; Department of Medical Oncology, Ballarat Health Services, Ballarat, VIC, Australia.
Issue Date: 1-May-2015
Citation: The Lancet. Oncology; 16(5): e234-45
Abstract: Cancers can evade the host immune system by inducing upregulation of immune inhibitory signals. Anti-programmed cell death-1 (PD-1) monoclonal antibodies block these inhibitory signals allowing the host to mount an immune response against malignant cells. This class of drugs is active in solid tumours, where upregulation of cell-surface PD-1 ligand proteins is nearly uniform. Because lymphoma is a malignancy of immune system cells, the role of the PD-1 pathway in these neoplasms is more complex. However, early clinical trials using PD-1 inhibitors have shown significant clinical activity in various subtypes of relapsed lymphoma. In this Review, we assess the scientific literature on the role of the PD-1 pathway in lymphoma, the relevant clinical data for PD-1 inhibition, and future strategies for this next generation of anticancer agents.
Internal ID Number: 25943068
URI: http://ahro.austin.org.au/austinjspui/handle/1/12781
DOI: 10.1016/S1470-2045(15)70103-8
URL: http://www.ncbi.nlm.nih.gov/pubmed/25943068
Type: Journal Article
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.