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Title: Serotonin in panic disorder: platelet uptake and concentration.
Authors: McIntyre, I M;Judd, F K;Burrows, Graham D;Norman, Trevor R
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Vic., Australia.
Issue Date: 1-Jan-1989
Citation: International Clinical Psychopharmacology; 4(1): 1-6
Abstract: Platelet serotonin uptake and platelet serotonin concentrations were measured in 17 patients (5 males, 12 females) with panic attacks and 15 controls (8 males, 7 females). Higher Vmax values were found in the patient group compared with controls (65 +/- 7 vs. 47 +/- 3 pmol/10(8) platelets/min; p less than 0.05) while the affinity constant Km was not significantly different (0.6 +/- 0.1 vs. 0.5 +/- 0.1 microM). Platelet serotonin concentrations were not significantly different between the two groups (38 +/- 4 vs. 41 +/- 4 ng/10(8) platelets). These results confirm our earlier finding of increased serotonin uptake in patients with panic attacks and suggest that platelet serotonin levels are normal.
Internal ID Number: 2592755
Type: Journal Article
Subjects: Adult
Blood Platelets.metabolism
Appears in Collections:Journal articles

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