Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12678
Title: The role of p21-activated kinases in pancreatic cancer.
Authors: Yeo, Dannel;He, Hong;Baldwin, Graham S;Nikfarjam, Mehrdad
Affiliation: From the Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria, Australia.
Issue Date: 1-Apr-2015
Citation: Pancreas; 44(3): 363-9
Abstract: Pancreatic cancer is an aggressive cancer with a poor prognosis and an overall 5-year survival rate of less than 5%. Management has not improved significantly over the last 30 years, and a better understanding of the genetic and molecular changes that occur is urgently required. Many of these changes appear to involve the p21-activated kinases (PAKs). The PAK family consists of 6 isoforms, 2 of which, PAK1 and PAK4, are up-regulated and/or hyperactivated in pancreatic cancer. p21-Activated kinases can mediate many different cellular processes especially those contributing to cancer development and progression. These processes include the regulation of cytoskeletal dynamics and cell adhesion, the evasion of apoptosis, and the promotion of cell survival, proliferation, migration, and invasion. p21-Activated kinases may also be involved in characteristics unique to pancreatic tumors, such as interplay with the pancreatic stroma, the re-emergence of embryonic pathways, and the involvement of a subset of microRNAs and heat shock proteins. This review highlights the potential role of PAKs in pancreatic cancer and provides a foundation for more effective therapeutics to improve our current treatment of pancreatic cancer.
Internal ID Number: 25760284
URI: http://ahro.austin.org.au/austinjspui/handle/1/12678
DOI: 10.1097/MPA.0000000000000276
URL: http://www.ncbi.nlm.nih.gov/pubmed/25760284
Type: Journal Article
Appears in Collections:Journal articles

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