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|Title:||Overview of the study protocols and statistical analysis plan for the Saline versus Plasma-Lyte 148 for Intravenous Fluid Therapy (SPLIT) research program.|
|Authors:||Reddy, Sumeet K;Young, Paul J;Beasley, Richard W;Mackle, Diane M;McGuinness, Shay P;McArthur, Colin J;Henderson, Seton J;Weinberg, Laurence;French, Craig J;Orford, Neil R;Bailey, Michael J;Bellomo, Rinaldo|
|Affiliation:||Intensive Care Unit, The Western Hospital, Melbourne, VIC, Australia|
Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia
Department of Anaesthesia, Austin Hospital, Melbourne, VIC, Australia
Intensive Care Unit, Geelong Hospital, Geelong, VIC, Australia
Medical Research Institute of New Zealand, Wellington, New Zealand. firstname.lastname@example.org.
Medical Research Institute of New Zealand, Wellington, New Zealand.
Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.
|Citation:||Critical Care and Resuscitation; 17(1): 29-36|
|Abstract:||0.9% saline is the most commonly used intravenous (IV) fluid in the world but recent data raise the possibility that, compared with buffered crystalloid fluids such as Plasma-Lyte 148, the administration of 0.9% saline might increase the risk of developing acute kidney injury.To provide an overview of the study protocols and statistical analysis plan for the six studies making up the (0.9% Saline v Plasma-Lyte 148 for Intravenous Fluid Therapy (SPLIT) research program.The SPLIT study consists of six integrated clinical trials, including a double-blind, cluster, randomised, double-crossover study in intensive care unit patients, incorporating two nested studies within it; an open-label, before-and-after study in emergency department (ED) patients; a single-centre, double-blind, crossover trial in major surgical patients; and a randomised, double-blind study in ICU patients. All studies focus on biochemical and renal outcomes but will also provide preliminary data on patient-centred outcomes including inhospital mortality and requirements for dialysis.The SPLIT study program will provide preliminary data on the comparative effectiveness of using 0.9% saline v Plasma-Lyte 148 for IV fluid therapy in ED, surgical and ICU patients.|
|Internal ID Number:||25702759|
|Subjects:||Acute Kidney Injury.etiology|
Gluconates.administration & dosage
Magnesium Chloride.administration & dosage
Potassium Chloride.administration & dosage
Randomized Controlled Trials as Topic
Sodium Acetate.administration & dosage
Sodium Chloride.administration & dosage.adverse effects
|Appears in Collections:||Journal articles|
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