Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12642
Title: Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer.
Authors: Pereira, Lloyd;Mariadason, John M;Hannan, Ross D;Dhillon, Amardeep S
Affiliation: Research Division, Peter MacCallum Cancer Centre , Melbourne, VIC , Australia.
Olivia Newton-John Cancer Research Institute, Austin Hospital , Melbourne, VIC , Australia.
Research Division, Peter MacCallum Cancer Centre , Melbourne, VIC , Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne , Melbourne, VIC , Australia ; Department of Biochemistry and Molecular Biology, The University of Melbourne , Melbourne, VIC , Australia.
Research Division, Peter MacCallum Cancer Centre , Melbourne, VIC , Australia ; Sir Peter MacCallum Department of Oncology, The University of Melbourne , Melbourne, VIC , Australia ; Department of Pathology, The University of Melbourne , Melbourne, VIC , Australia.
Issue Date: 2-Feb-2015
Citation: Frontiers in Oncology 2015; 5(): 13
Abstract: Colorectal cancer (CRC) is a genetically heterogeneous disease that develops and progresses through several distinct pathways characterized by genomic instability. In recent years, it has emerged that inherent plasticity in some populations of CRC cells can contribute to heterogeneity in differentiation state, metastatic potential, therapeutic response, and disease relapse. Such plasticity is thought to arise through interactions between aberrant signaling events, including persistent activation of the APC/β-catenin and KRAS/BRAF/ERK pathways, and the tumor microenvironment. Here, we highlight key concepts and evidence relating to the role of epithelial-mesenchymal plasticity as a driver of CRC progression and stratification of the disease into distinct molecular and clinicopathological subsets.
Internal ID Number: 25699236
URI: http://ahro.austin.org.au/austinjspui/handle/1/12642
DOI: 10.3389/fonc.2015.00013
URL: http://www.ncbi.nlm.nih.gov/pubmed/25699236
Type: Journal Article
Subjects: CRC
cancer stem cell
epithelial–mesenchymal transition
serrated
subtypes
tumor progression
Appears in Collections:Journal articles

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