Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12611
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dc.contributor.authorPalmer, Susan Men
dc.contributor.authorCrewther, Sheila Gen
dc.contributor.authorCarey, Leeanne Men
dc.date.accessioned2015-05-16T02:19:41Z
dc.date.available2015-05-16T02:19:41Z
dc.date.issued2015-01-14en
dc.identifier.citationFrontiers in Human Neuroscience 2015; 8(): 1045en
dc.identifier.govdoc25642179en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12611en
dc.description.abstractInsights into neurobiological mechanisms of depression are increasingly being sought via brain imaging studies. Our aim was to quantitatively summarize overlap and divergence in regions of altered brain activation associated with depression under emotionally valenced compared to cognitively demanding task conditions, and with reference to intrinsic functional connectivity. We hypothesized differences reflective of task demands. A co-ordinate-based meta-analysis technique, activation likelihood estimation, was used to analyze relevant imaging literature. These studies compared brain activity in depressed adults relative to healthy controls during three conditions: (i) emotionally valenced (cognitively easy) tasks (n = 29); (ii) cognitively demanding tasks (n = 15); and (iii) resting conditions (n = 21). The meta-analyses identified five, eight, and seven significant clusters of altered brain activity under emotion, cognition, and resting conditions, respectively, in depressed individuals compared to healthy controls. Regions of overlap and divergence between pairs of the three separate meta-analyses were quantified. There were no significant regions of overlap between emotion and cognition meta-analyses, but several divergent clusters were found. Cognitively demanding conditions were associated with greater activation of right medial frontal and insula regions while bilateral amygdala was more significantly altered during emotion (cognitively undemanding) conditions; consistent with task demands. Overlap was present in left amygdala and right subcallosal cingulate between emotion and resting meta-analyses, with no significant divergence. Our meta-analyses highlight alteration of common brain regions, during cognitively undemanding emotional tasks and resting conditions but divergence of regions between emotional and cognitively demanding tasks. Regions altered reflect current biological and system-level models of depression and highlight the relationship with task condition and difficulty.en
dc.language.isoenen
dc.subject.otherbrain networksen
dc.subject.othercognitionen
dc.subject.otherdepressionen
dc.subject.otheremotionen
dc.subject.otherfMRIen
dc.subject.othermeta-analysisen
dc.subject.otherresting stateen
dc.subject.othertask activationen
dc.titleA meta-analysis of changes in brain activity in clinical depression.en
dc.typeJournal Articleen
dc.identifier.journaltitleFrontiers in human neuroscienceen
dc.identifier.affiliationNeurorehabilitation and Recovery, Stroke Division, The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre , Heidelberg, VIC , Australia ; Department of Occupational Therapy, School of Allied Health, La Trobe University , Bundoora, VIC , Australiaen
dc.identifier.affiliationNeurorehabilitation and Recovery, Stroke Division, The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre , Heidelberg, VIC , Australiaen
dc.identifier.affiliationNeurorehabilitation and Recovery, Stroke Division, The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre , Heidelberg, VIC , Australia ; School of Psychological Science, La Trobe University , Bundoora, VIC , Australiaen
dc.identifier.doi10.3389/fnhum.2014.01045en
dc.description.pages1045en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25642179en
dc.contributor.corpauthorSTART Project Teamen
dc.type.austinJournal Articleen
local.name.researcherCarey, Leeanne M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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