Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12605
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dc.contributor.authorLeung, Christopher-
dc.contributor.authorYeoh, Sern Wei-
dc.contributor.authorPatrick, Desmond-
dc.contributor.authorKet, Shara-
dc.contributor.authorMarion, Kaye-
dc.contributor.authorGow, Paul J-
dc.contributor.authorAngus, Peter W-
dc.date.accessioned2015-05-16T02:19:19Z
dc.date.available2015-05-16T02:19:19Z
dc.date.issued2015-01-28-
dc.identifier.citationWorld Journal of Gastroenterology; 21(4): 1189-96en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12605en
dc.description.abstractTo determine characteristics and prognostic predictors of patients with hepatocellular carcinoma (HCC) in association with non-alcoholic fatty liver disease (NAFLD).We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index (BMI), and the presence of diabetes, hypertension, or dyslipidaemia.Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent (8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of <25 kg/m2, 25-29 kg/m2 and ≥30 kg/m2 respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics (P=0.041). Multivariate analysis did not identify any other patient characteristics that predicted the size or number of HCC.HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis.en_US
dc.language.isoenen
dc.subject.otherCryptogenic cirrhosisen
dc.subject.otherHepatocellular carcinomaen
dc.subject.otherMetabolic syndromeen
dc.subject.otherNon-alcoholic fatty liver diseaseen
dc.subject.otherScreeningen
dc.titleCharacteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleWorld Journal of Gastroenterologyen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.doi10.3748/wjg.v21.i4.1189en_US
dc.description.pages1189-96en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25632192en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptUniversity of Melbourne Clinical School-
crisitem.author.deptClinical Education-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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