Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12605
Title: Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease.
Authors: Leung, Christopher;Yeoh, Sern Wei;Patrick, Desmond;Ket, Shara;Marion, Kaye;Gow, Paul J;Angus, Peter W
Affiliation: Christopher Leung, Sern Wei Yeoh, Desmond Patrick, Shara Ket, Paul Gow, Peter W Angus, Liver Transplant Unit, Austin Hospital, Heidelberg, Victoria 3084, Australia
Issue Date: 28-Jan-2015
Citation: World Journal of Gastroenterology; 21(4): 1189-96
Abstract: To determine characteristics and prognostic predictors of patients with hepatocellular carcinoma (HCC) in association with non-alcoholic fatty liver disease (NAFLD).We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index (BMI), and the presence of diabetes, hypertension, or dyslipidaemia.Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent (8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of <25 kg/m2, 25-29 kg/m2 and ≥30 kg/m2 respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics (P=0.041). Multivariate analysis did not identify any other patient characteristics that predicted the size or number of HCC.HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis.
Internal ID Number: 25632192
URI: http://ahro.austin.org.au/austinjspui/handle/1/12605
DOI: 10.3748/wjg.v21.i4.1189
URL: http://www.ncbi.nlm.nih.gov/pubmed/25632192
Type: Journal Article
Subjects: Cryptogenic cirrhosis
Hepatocellular carcinoma
Metabolic syndrome
Non-alcoholic fatty liver disease
Screening
Appears in Collections:Journal articles

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