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dc.contributor.authorWoods, Katherineen
dc.contributor.authorPasam, Anupamaen
dc.contributor.authorJayachandran, Aparnaen
dc.contributor.authorAndrews, Miles Cen
dc.contributor.authorCebon, Jonathan Sen
dc.identifier.citationFrontiers in Oncology 2014; 4(): 367en
dc.description.abstractMelanoma cells can switch phenotype in a manner similar to epithelial to mesenchymal transition (EMT). In this perspective article, we address the effects of such phenotype switching on T cell targeting of tumor cells. During the EMT-like switch in phenotype, a concomitant change in expression of multiple tumor antigens occurs. Melanoma cells undergoing EMT escape from killing by T cells specific for antigens whose expression is downregulated by this process. We discuss melanoma antigens whose expression is influenced by EMT. We assess the effect of changes in the expressed tumor antigen repertoire on T-cell mediated tumor recognition and killing. In addition to escape from T cell immunity via changes in antigen expression, mesenchymal-like melanoma cells are generally more resistant to classical chemotherapy and radiotherapy. However, we demonstrate that when targeting antigens whose expression is unaltered during EMT, the capacity of T cells to kill melanoma cell lines in vitro is not influenced by their phenotype. When considering immune therapies such as cancer vaccination, these data suggest escape from T cell killing due to phenotype switching in melanoma could potentially be avoided by careful selection of target antigen.en
dc.subject.otherT cell killingen
dc.subject.othercancer testis antigensen
dc.subject.otherepithelial–mesenchymal transitionen
dc.subject.othertumor antigensen
dc.titleEffects of epithelial to mesenchymal transition on T cell targeting of melanoma cells.en
dc.typeJournal Articleen
dc.identifier.journaltitleFrontiers in oncologyen
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationCancer Immunobiology Laboratory,Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationOlivia Newton John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australiaen
Appears in Collections:Journal articles

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