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dc.contributor.authorVella, Laura Jayneen
dc.identifier.citationFrontiers in Oncology 2014; 4: 361en
dc.description.abstractMetastasis in cancer consists of multiple steps, including epithelial-mesenchymal-transition (EMT), which is characterized by the loss of epithelial-like characteristics and the gain of mesenchymal-like attributes including cell migration and invasion. It is clear that the tumor microenvironment can promote the metastatic cascade and that intercellular communication is necessary for this to occur. Exosomes are small membranous vesicles secreted by most cell types into the extracellular environment and they are important communicators in the tumor microenvironment. They promote angiogenesis, invasion, and proliferation in recipient cells to support tumor growth and a prometastatic phenotype. Although it is clear that exosomes contribute to cancer cell plasticity, experimental evidence to define exosome induced plasticity as EMT is only just coming to light. This review will discuss recent research on exosomal regulation of the EMT process in the tumor microenvironment.en
dc.subject.otherextracellular vesiclesen
dc.subject.otherintercellular signalingen
dc.titleThe emerging role of exosomes in epithelial-mesenchymal-transition in cancer.en
dc.typeJournal Articleen
dc.identifier.journaltitleFrontiers in oncologyen
dc.identifier.affiliationLudwig Institute for Cancer Research, Melbourne-Austin Branch, Cancer Immunobiology Laboratory, Olivia Newton-John Cancer and Wellness Centre , Heidelberg, VIC , Australia ; The Florey Institute for Neuroscience and Mental Health , Parkville, VIC , Australiaen
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