Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12560
Title: Quantitative proteomics of bronchoalveolar lavage fluid in lung adenocarcinoma.
Authors: Almatroodi, Saleh A;McDonald, Christine F;Collins, Allison L;Darby, Ian A;Pouniotis, Dodie S
Affiliation: Cancer and Tissue Repair Laboratory, School of Medical Sciences, RMIT University, Bundoora, VIC, Australia Applied Medical Sciences College, Qassim University, Buraidah, Saudi Arabia.
Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC, Australia.
Cancer and Tissue Repair Laboratory, School of Medical Sciences, RMIT University, Bundoora, VIC, Australia.
Issue Date: 2-Jan-2015
Citation: Cancer Genomics & Proteomics; 12(1): 39-48
Abstract: The most commonly reported primary lung cancer subtype is adenocarcinoma, which is associated with a poor prognosis and short survival. Proteomic studies on human body fluids such as bronchoalveolar lavage fluid (BALF) have become essential methods for biomarker discovery, examination of tumor pathways and investigation of potential treatments.This study used quantitative proteomics to investigate the up-regulation of novel proteins in BALF from patients with primary lung adenocarcinoma in order to identify potential biomarkers.BALF samples from individuals with and without primary lung adenocarcinoma were analyzed using liquid chromatography-mass spectrometry.One thousand and one hundred proteins were identified, 33 of which were found to be consistently overexpressed in all lung adenocarcinoma samples compared to non-cancer controls. A number of overexpressed proteins have been previously shown to be related to lung cancer progression including S100-A8, annexin A1, annexin A2, thymidine phosphorylase and transglutaminase 2.The overexpression of a number of specific proteins in BALF from patients with primary lung adenocarcinoma may be used as a potential biomarker for lung adenocarcinoma.
Internal ID Number: 25560643
URI: http://ahro.austin.org.au/austinjspui/handle/1/12560
URL: http://www.ncbi.nlm.nih.gov/pubmed/25560643
Type: Journal Article
Subjects: BALF
Lung adenocarcinoma
biomarker
mass spectrophotometry
protein
quantitative proteomics
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.