Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12545
Title: The piriform cortex and human focal epilepsy.
Authors: Vaughan, David N;Jackson, Graeme D
Affiliation: Florey Institute of Neuroscience and Mental Health , Heidelberg, VIC , Australia ; Department of Neurology, Austin Health , Heidelberg, VIC , Australia ; Department of Medicine, University of Melbourne , Melbourne, VIC , Australia
Florey Institute of Neuroscience and Mental Health , Heidelberg, VIC , Australia ; Department of Neurology, Austin Health , Heidelberg, VIC , Australia
Issue Date: 8-Dec-2014
Citation: Frontiers in Neurology 2014; 5(): 259
Abstract: It is surprising that the piriform cortex, when compared to the hippocampus, has been given relatively little significance in human epilepsy. Like the hippocampus, it has a phylogenetically preserved three-layered cortex that is vulnerable to excitotoxic injury, has broad connections to both limbic and cortical areas, and is highly epileptogenic - being critical to the kindling process. The well-known phenomenon of early olfactory auras in temporal lobe epilepsy highlights its clinical relevance in human beings. Perhaps because it is anatomically indistinct and difficult to approach surgically, as it clasps the middle cerebral artery, it has, until now, been understandably neglected. In this review, we emphasize how its unique anatomical and functional properties, as primary olfactory cortex, predispose it to involvement in focal epilepsy. From recent convergent findings in human neuroimaging, clinical epileptology, and experimental animal models, we make the case that the piriform cortex is likely to play a facilitating and amplifying role in human focal epileptogenesis, and may influence progression to epileptic intractability.
Internal ID Number: 25538678
URI: http://ahro.austin.org.au/austinjspui/handle/1/12545
DOI: 10.3389/fneur.2014.00259
URL: http://www.ncbi.nlm.nih.gov/pubmed/25538678
Type: Journal Article
Subjects: EEG-fMRI
area tempestas
claustrum
intracranial electrodes
olfaction
olfactory aura
pyriform
temporal lobe epilepsy
Appears in Collections:Journal articles

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