Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12537
Title: Cyclosporine increases endothelin-1 binding site density in cardiac cell membranes.
Authors: Nayler, W G;Gu, X H;Casley, David J;Panagiotopoulos, Sianna;Liu, J;Mottram, P L
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Victoria, Australia.
Issue Date: 29-Sep-1989
Citation: Biochemical and Biophysical Research Communications; 163(3): 1270-4
Abstract: When used in high concentrations, the immunosuppressive agent cyclosporine A has toxic side effects, including cardiac fibrosis and calcification. Cyclosporine-treated mice were used to investigate whether a cyclosporine dose regime which produces cardiac fibrosis and calcification alters the density of the specific binding sites for the endothelial-derived vasoconstrictor polypeptide, endothelin-1. After twenty-one days of treatment the endothelin-1 binding site density in cardiac cell membranes was increased, without any change in selectivity. This increase in endothelin-1 binding site density could contribute to the cytotoxic effects of cyclosporine.
Internal ID Number: 2551284
URI: http://ahro.austin.org.au/austinjspui/handle/1/12537
ORCID: 0000-0002-0845-0001
URL: http://www.ncbi.nlm.nih.gov/pubmed/2551284
Type: Journal Article
Subjects: Animals
Cell Membrane.metabolism
Cyclosporins.pharmacology.toxicity
Endothelins
Endothelium, Vascular
Heart.drug effects
Kinetics
Mice
Mice, Inbred CBA
Myocardium.metabolism
Peptides.metabolism
Receptors, Cell Surface.drug effects.metabolism
Receptors, Endothelin
Reference Values
Appears in Collections:Journal articles

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