Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12523
Title: A gelatin liver phantom of suspended 90Y resin microspheres to simulate the physiologic microsphere biodistribution of a postradioembolization liver.
Authors: Kao, Yung Hsiang;Luddington, Oliver S;Culleton, Simone R;Francis, Roslyn J;Boucek, Jan A
Affiliation: Department of Nuclear Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia Department of Nuclear Medicine, Austin Hospital, Melbourne, Victoria, Australia; and yung.h.kao@gmail.com.
Department of Nuclear Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Department of Nuclear Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
Issue Date: 13-Nov-2014
Citation: Journal of Nuclear Medicine Technology 2014; 42(4): 265-8
Abstract: For phantom studies involving (90)Y PET/CT, homogeneous solutions of (90)Y, for example, (90)Y citrate, are commonly used. However, the microsphere biodistribution of a postradioembolization liver is never homogeneous; therefore, such phantoms are physiologically unrealistic for simulating clinical scenarios. The aim of this work was to develop a safe and practical phantom capable of simulating the heterogeneous microsphere biodistribution of a postradioembolization liver.Gelatin (5%) was used to suspend (90)Y resin microspheres, poured into plastic containers to simulate a liver with 2 tumors. Microspheres were added while the gelatin was maintained in a liquid state on a hot plate and continuously stirred with magnetic stir bars. The liquid microsphere mixture was then rapidly cooled in an ice bath while being stirred, resulting in a heterogeneous suspension of microspheres. The completed phantom was serially scanned by (90)Y PET/CT over 2 wk.All scans demonstrated a heterogeneous microsphere distribution throughout the liver and tumor inserts. Serendipitously, magnetic stir bars left inside the phantom produced CT artifacts similar to those caused by embolization coils, whereas pockets of air trapped within the gelatin during its preparation mimicked gas within hollow viscus. The microspheres and tumor inserts remained fixed and suspended within the gelatin, with no evidence of breakdown or leakage.A gelatin phantom realistically simulating the physiologic microsphere biodistribution of a postradioembolization liver is feasible to construct in a radiopharmacy.
Internal ID Number: 25472514
URI: http://ahro.austin.org.au/austinjspui/handle/1/12523
DOI: 10.2967/jnmt.114.145292
URL: http://www.ncbi.nlm.nih.gov/pubmed/25472514
Type: Journal Article
Subjects: 90Y PET/CT
90Y radioembolization
phantom
radiopharmacy
selective internal radiation therapy
Appears in Collections:Journal articles

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