Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12521
Title: Relationships between performance on the Cogstate Brief Battery, neurodegeneration, and Aβ accumulation in cognitively normal older adults and adults with MCI.
Authors: Lim, Yen Ying;Pietrzak, Robert H;Bourgeat, Pierrick;Ames, David;Ellis, Kathryn A;Rembach, Alan;Harrington, Karra;Salvado, Olivier;Martins, Ralph N;Snyder, Peter J;Masters, Colin L;Rowe, Christopher C;Villemagne, Victor L;Maruff, Paul
Affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia Department of Neurology, Warren Alpert School of Medicine, Brown University, Providence, RI, USA yen_ying_lim@brown.edu.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Commonwealth Scientific Industrial Research Organization Preventative Health National Research Flagship, Australian e-Health Research Centre-BioMedIA, Brisbane, QLD, Australia.
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, VIC, Australia National Ageing Research Institute, Parkville, VIC, Australia.
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, VIC, Australia National Ageing Research Institute, Parkville, VIC, Australia.
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, WA, Australia.
Department of Neurology, Warren Alpert School of Medicine, Brown University, Providence, RI, USA.
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, VIC, Australia.
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, VIC, Australia.
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia Cogstate Ltd., Melbourne, VIC, Australia.
Issue Date: 2-Dec-2014
Citation: Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists 2014; 30(1): 49-58
Abstract: We investigated the extent to which decline in memory and working memory in beta-amyloid (Aβ) positive non-demented individuals was related to hippocampal atrophy and Aβ accumulation over 36 months. Cognitively normal older adults (CN) (n = 178) and adults with mild cognitive impairment (MCI) (n = 49) underwent positron emission tomography neuroimaging, magnetic resonance imaging, and cognitive assessments at baseline, 18- and 36-months. Relative to Aβ- CNs, Aβ+ CNs and Aβ+ MCIs showed greater rates of cognitive decline, Aβ accumulation, and hippocampal atrophy. Analysis of interrelationships between these Alzheimer's disease markers in Aβ+ CNs and MCIs indicated that rate of Aβ accumulation was associated with rate of hippocampal atrophy (β = -0.05, p = .037), which was in turn associated independently with rate of decline in memory (β = -0.03, p = .032). This suggests that Aβ accumulation precedes any neurodegeneration or clinical symptoms, and that the relationship between Aβ and cognitive decline is mediated by hippocampal atrophy.
Internal ID Number: 25467942
URI: http://ahro.austin.org.au/austinjspui/handle/1/12521
DOI: 10.1093/arclin/acu068
URL: http://www.ncbi.nlm.nih.gov/pubmed/25467942
Type: Journal Article
Subjects: Episodic memory
Hippocampal volume
MCI
Neuropsychological assessment
Preclinical AD
β-amyloid
Appears in Collections:Journal articles

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