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dc.contributor.authorPerera, Marlonen
dc.contributor.authorRoberts, Matthew Jen
dc.contributor.authorDoi, Suhail A Ren
dc.contributor.authorBolton, Damien Men
dc.identifier.citationEuropean Urology 2014; 67(4): 704-13en
dc.description.abstractTreatment for lower urinary tract symptoms resulting from benign prostatic hyperplasia (BPH) is varied, and significant side effects, particularly concerning sexual function, affect uptake. The prostatic urethral lift (PUL) procedure is a recent addition to the armamentarium for BPH treatment, with independent reports suggesting improvement of symptoms, sexual function, and urinary flow.We undertook a systematic review and meta-analysis of reported symptomatic, functional, and sexual outcomes following the PUL procedure.We performed a critical review of Medline, Embase, ScienceDirect, Cochrane Library, and Web of Science databases in May 2014 according to the Preferred Reporting Items for Systematic Review and Meta-Analysis statement. Quality assessment was performed using a modification of the Methodological Index for Non-Randomized Studies tool. All retrospective, prospective, and controlled trials were included for analysis. Symptom scores, sexual health scores, and functional outcomes were pooled and meta-analysed using quality and random-effects models.Ten articles comprising six independent patient cohorts were included for analysis. Pooled estimates from between 452 and 680 patients suggested overall improvement following PUL, including symptoms (large gain; standardised mean gain range of 1.3-1.6, International Prostate Symptom Score difference of -7.2 to -8.7 points), maximum flow rate (3.8-4.0 ml/s), and quality of life (2.2-2.4 points). Sexual function was preserved with a small improvement estimated at 12 mo (standardised mean gain range of 0.3-0.4). Pooled estimates were mostly heterogeneous across study groups.PUL is a well-tolerated, minimally invasive therapy for BPH that provides favourable symptom, sexual health, and functional outcomes during follow-up to 12 mo. Longer follow-up and larger randomised studies are required to further confirm these preliminary results.We reviewed the early results of an innovative procedure directed towards the management of prostate enlargement. The results revealed a well-tolerated procedure that produces improvement in urinary symptoms and function while preserving sexual function.en
dc.subject.otherBenign prostatic hyperplasiaen
dc.subject.otherLower urinary tract symptomsen
dc.subject.otherMinimally invasive surgical therapyen
dc.subject.otherProstatic urethral liften
dc.titleProstatic urethral lift improves urinary symptoms and flow while preserving sexual function for men with benign prostatic hyperplasia: a systematic review and meta-analysis.en
dc.typeJournal Articleen
dc.identifier.journaltitleEuropean Urologyen
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationCentre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australiaen
dc.identifier.affiliationDepartment of Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australiaen
dc.identifier.affiliationMackay Base Hospital, Mackay, Queensland, Australiaen
dc.identifier.affiliationUrological Society of Australia and New Zealand, Edgecliff, New South Wales, Australiaen
dc.identifier.affiliationSchool of Population Health, The University of Queensland, Brisbane, Queensland, Australiaen
dc.identifier.affiliationLudwig Institute for Cancer Research, Austin Hospital, Studley Road, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Medicine, The University of Queensland, Brisbane, Queensland, Australiaen
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