Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12514
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKohzuki, Men
dc.contributor.authorJohnston, Colin Ien
dc.contributor.authorChai, Syn Yen
dc.contributor.authorCasley, David Jen
dc.contributor.authorRogerson, Fen
dc.contributor.authorMendelsohn, Frederick AOen
dc.date.accessioned2015-05-16T02:13:18Z
dc.date.available2015-05-16T02:13:18Z
dc.date.issued1989-04-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 16(4): 239-42en
dc.identifier.govdoc2545391en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12514en
dc.description.abstract1. The radioligand [125I]-endothelin was used to map receptors for endothelin in rat adrenal gland using in vitro autoradiography and computerized densitometry. 2. In the adrenal, a high density of binding was found in the adrenal medulla (binding affinity constant 0.18 +/- 0.11 X 10(9)M-1) and zona glomerulosa (binding affinity constant 0.18 +/- 0.07 X 10(9)M-1). Binding was low to undetectable in the zona fasciculata and zona reticularis. Unrelated peptides did not displace endothelin. 3. These results provide evidence of endothelin receptor distribution in adrenal gland and suggest that endothelin might exert multiple actions in the adrenal gland on catecholamine and aldosterone biosynthesis and secretion.en
dc.language.isoenen
dc.subject.otherAdrenal Glands.metabolismen
dc.subject.otherAnimalsen
dc.subject.otherAutoradiographyen
dc.subject.otherDensitometryen
dc.subject.otherEndothelinsen
dc.subject.otherFemaleen
dc.subject.otherIodine Radioisotopes.diagnostic useen
dc.subject.otherPeptides.metabolism.pharmacologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Cell Surface.metabolismen
dc.subject.otherReceptors, Endothelinen
dc.titleEndothelin receptors in rat adrenal gland visualized by quantitative autoradiography.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationMelbourne University Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages239-42en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/2545391en
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.