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|Title:||Platelet serotonin uptake and 3H-imipramine binding in panic disorder.|
|Authors:||Norman, Trevor R;Sartor, Daniela M;Judd, F K;Burrows, Graham D;Gregory, M S;McIntyre, I M|
|Affiliation:||Department of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australia.|
|Citation:||Journal of Affective Disorders; 17(1): 77-81|
|Abstract:||Platelet serotonin uptake and 3H-imipramine binding were measured in eight patients with panic disorders and nine controls. The Vmax of serotonin uptake was significantly elevated in patients compared to controls (77 +/- 14 vs. 50 +/- 4 pmol/10(8) platelets/min; P less than 0.05) while Km values were not different (1.46 +/- 0.41 vs. 1.24 +/- 0.20 microM). 3H-Imipramine binding to ruptured platelet membranes was not significantly different between patients and controls for either Bmax (395 +/- 71 vs. 412 +/- 107 fmol/mg protein) or Kd (0.90 +/- 0.18 vs. 1.09 +/- 0.30 nM). The implications for a serotonergic dysfunction in panic disorders are discussed.|
|Internal ID Number:||2544638|
|Appears in Collections:||Journal articles|
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