Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12498
Title: Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors.
Authors: Chia, Puey Ling;Mitchell, Paul L R;Dobrovic, Alexander;John, Thomas
Affiliation: Department of Medical Oncology, Olivia-Newton John Cancer and Wellness Centre, Victoria, Australia.
Ludwig Institute for Cancer Research, Austin Health, Victoria, Australia ; Department of Pathology, University of Melbourne, Victoria, Australia ; School of Cancer Medicine, La Trobe University, Victoria, Australia.
Department of Medical Oncology, Olivia-Newton John Cancer and Wellness Centre, Victoria, Australia ; Ludwig Institute for Cancer Research, Austin Health, Victoria, Australia ; School of Cancer Medicine, La Trobe University, Victoria, Australia.
Issue Date: 20-Nov-2014
Citation: Clinical Epidemiology 2014; 6(): 423-32
Abstract: Improved understanding of molecular drivers of carcinogenesis has led to significant progress in the management of lung cancer. Patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) gene rearrangements constitute about 4%-5% of all NSCLC patients. ALK+ NSCLC cells respond well to small molecule ALK inhibitors such as crizotinib; however, resistance invariably develops after several months of treatment. There are now several newer ALK inhibitors, with the next generation of agents targeting resistance mutations. In this review, we will discuss the prevalence and clinical characteristics of ALK+ lung cancer, current treatment options, and future directions in the management of this subset of NSCLC patients.
Internal ID Number: 25429239
URI: http://ahro.austin.org.au/austinjspui/handle/1/12498
DOI: 10.2147/CLEP.S69718
URL: http://www.ncbi.nlm.nih.gov/pubmed/25429239
Type: Journal Article
Subjects: anaplastic lymphoma kinase (ALK)
gene rearrangements
kinase inhibitors
lung adenocarcinoma
lung cancer
Appears in Collections:Journal articles

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