Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12489
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dc.contributor.authorRodrigues, Paulo-
dc.contributor.authorMacaya, Irati-
dc.contributor.authorBazzocco, Sarah-
dc.contributor.authorMazzolini, Rocco-
dc.contributor.authorAndretta, Elena-
dc.contributor.authorDopeso, Higinio-
dc.contributor.authorMateo-Lozano, Silvia-
dc.contributor.authorBilić, Josipa-
dc.contributor.authorCartón-García, Fernando-
dc.contributor.authorNieto, Rocio-
dc.contributor.authorSuárez-López, Lucia-
dc.contributor.authorAfonso, Elsa-
dc.contributor.authorLandolfi, Stefania-
dc.contributor.authorHernandez-Losa, Javier-
dc.contributor.authorKobayashi, Kazuto-
dc.contributor.authorCajal, Santiago Ramón Y-
dc.contributor.authorTabernero, Josep-
dc.contributor.authorTebbutt, Niall C-
dc.contributor.authorMariadason, John M-
dc.contributor.authorSchwartz, Simo-
dc.contributor.authorArango, Diego-
dc.date.accessioned2015-05-16T02:11:38Z
dc.date.available2015-05-16T02:11:38Z
dc.date.issued2014-11-21-
dc.identifier.citationNature Communications 2014; 5(): 5458en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12489en
dc.description.abstractActivation of the small GTPase RHOA has strong oncogenic effects in many tumour types, although its role in colorectal cancer remains unclear. Here we show that RHOA inactivation contributes to colorectal cancer progression/metastasis, largely through the activation of Wnt/β-catenin signalling. RhoA inactivation in the murine intestine accelerates the tumorigenic process and in human colon cancer cells leads to the redistribution of β-catenin from the membrane to the nucleus and enhanced Wnt/β-catenin signalling, resulting in increased proliferation, invasion and de-differentiation. In mice, RHOA inactivation contributes to colon cancer metastasis and reduced RHOA levels were observed at metastatic sites compared with primary human colon tumours. Therefore, we have identified a new mechanism of activation of Wnt/β-catenin signalling and characterized the role of RHOA as a novel tumour suppressor in colorectal cancer. These results constitute a shift from the current paradigm and demonstrate that RHO GTPases can suppress tumour progression and metastasis.en
dc.language.isoenen
dc.titleRHOA inactivation enhances Wnt signalling and promotes colorectal cancer.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature Communicationsen
dc.identifier.affiliationLudwig Institute for Cancer Research, Melbourne-Branch, Austin Health, Heidelberg, Victoria 3084, Australiaen
dc.identifier.affiliationCIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spainen
dc.identifier.affiliationCIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Barcelona, Spain.en
dc.identifier.affiliationGroup of Drug Delivery and Targeting, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain.en
dc.identifier.affiliationGroup of Molecular Oncology, CIBBIM-Nanomedicine, Vall d'Hebron University Hospital, Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spainen
dc.identifier.affiliationDepartment of Pathology, Vall d'Hebron Hospital, Passeig Vall d'Hebron, 119-129, Barcelona 08035, Spain.en
dc.identifier.affiliationDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.en
dc.identifier.affiliationDepartment of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, 119-129, Barcelona 08035, Spain.en
dc.identifier.doi10.1038/ncomms6458en
dc.description.pages5458en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25413277en
dc.type.contentTexten
dc.type.austinJournal Articleen
local.name.researcherMariadason, John M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedical Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
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