Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12488
Title: Effects of selective β1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis.
Authors: Calzavacca, Paolo;Lankadeva, Yugeesh R;Bailey, Simon R;Bailey, Michael J;Bellomo, Rinaldo;May, Clive N
Affiliation: Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia. p.calzavacca@gmail.com.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia. yugeesh.lankadeve@monash.edu.
Faculty of Veterinary Science, University of Melbourne, Corner Park Drive and Flemington Road, Melbourne, VIC, 3052, Australia. bais@unimelb.edu.au.
Australian and New Zealand Intensive Care Research Centre, Monash University, Wellington Road, Clayton, VIC, 3800, Australia. Michael.Bailey@monash.edu.
Department of Intensive Care and Department of Medicine, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia. Rinaldo.bellomo@austin.org.au.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, VIC, 3052, Australia. clive.may@florey.edu.au.
Issue Date: 21-Nov-2014
Citation: Critical Care (london, England) 2014; 18(6): 610
Abstract: Activation of the sympathetic nervous system has beneficial cardiovascular effects in sepsis, but there is also evidence that sympatholytics have beneficial actions in sepsis. We therefore determined the effect of selective β1-adrenoceptor blockade on cardiac and renal function and cytokine release in ovine hyperdynamic sepsis.Hyperdynamic sepsis was induced by infusion of live E. coli for 24 hours in nine conscious sheep instrumented with flow probes on the pulmonary and left renal artery. Cardiovascular and renal function and levels of plasma cytokines were determined in a control group and during selective β1-adrenoceptor blockade with atenolol (10 mg intravenous bolus then 0.125 mg/kg/h) from 8 to 24 hours of sepsis.Hyperdynamic sepsis was characterized by hypotension with increases in cardiac output (CO), heart rate (HR) and renal blood flow (RBF), and acute kidney injury. Atenolol caused sustained reductions in HR (P <0.001) and CO (P <0.001). Despite the lower CO the sepsis-induced fall in mean arterial pressure (MAP) was similar in both groups. The sepsis-induced increase in RBF, decrease in renal function and increase in arterial lactate were unaffected by atenolol. Sepsis increased plasma levels of tumour necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and IL-10. Atenolol caused a further increase in IL-10, but did not affect levels of TNF-α or IL-6.In sepsis, selective β1-adrenoceptor blockade reduced CO, but not MAP. During sepsis, atenolol did not alter the development of acute kidney injury or the levels of pro-inflammatory cytokines, but enhanced the release of IL-10. Atenolol appears safe in sepsis, has no deleterious cardiovascular or renal effects, and has an anti-inflammatory effect.
Internal ID Number: 25413250
URI: http://ahro.austin.org.au/austinjspui/handle/1/12488
DOI: 10.1186/s13054-014-0610-1
URL: http://www.ncbi.nlm.nih.gov/pubmed/25413250
Type: Journal Article
Appears in Collections:Journal articles

Files in This Item:
File Description SizeFormat 
25413250.pdf779.48 kBAdobe PDFThumbnail
View/Open


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.