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Title: Bidirectional transport of NMDA receptor and ionophore in the vagus nerve.
Authors: Cincotta, M;Beart, P M;Summers, R J;Lodge, D
Affiliation: University of Melbourne, Austin Hospital, Heidelberg, Vic., Australia
Issue Date: 24-Jan-1989
Citation: European Journal of Pharmacology; 160(1): 167-71
Abstract: Accumulations of binding sites for [3H]3-[+-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic ([3H]CPP) and [3H]-N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine ([3H]TCP) were demonstrated both proximal and distal to 24-h ligatures of the central and peripheral vagus nerve in the rat using radioligand binding and autoradiography. Peaks of label occurred at the proximal and distal extremities of double ligations but not between the ligatures, or in sham-operated or colchicine-treated nerves. Together these results suggest that both the primary acceptor site and the ionophore of the N-methyl-D-aspartate receptor undergo bidirectional axonal transport in central and peripheral branches of the vagus nerve.
Internal ID Number: 2540989
Type: Journal Article
Subjects: Animals
Phencyclidine.analogs & derivatives.metabolism.toxicity
Rats, Inbred Strains
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter.metabolism
Vagus Nerve.metabolism
Appears in Collections:Journal articles

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