Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12477
Title: Conceptualizing lennox-gastaut syndrome as a secondary network epilepsy.
Authors: Archer, John S;Warren, Aaron E L;Jackson, Graeme D;Abbott, David F
Affiliation: Department of Medicine, Austin Health, The University of Melbourne , Heidelberg, VIC , Australia.
Department of Medicine, Austin Health, The University of Melbourne , Heidelberg, VIC , Australia ; Florey Institute of Neuroscience and Mental Health , Heidelberg, VIC , Australia ; Department Neurology, Austin Health , Heidelberg, VIC , Australia.
Department of Medicine, Austin Health, The University of Melbourne , Heidelberg, VIC , Australia ; Florey Institute of Neuroscience and Mental Health , Heidelberg, VIC , Australia.
Issue Date: 30-Oct-2014
Citation: Frontiers in Neurology 2014; 5(): 225
Abstract: Lennox-Gastaut Syndrome (LGS) is a category of severe, disabling epilepsy, characterized by frequent, treatment-resistant seizures, and cognitive impairment. Electroencephalography (EEG) shows characteristic generalized epileptic activity that is similar in those with lesional, genetic, or unknown causes, suggesting a common underlying mechanism. The condition typically begins in young children, leaving many severely disabled with recurring seizures throughout their adult life. Scalp EEG of the tonic seizures of LGS is characterized by a diffuse high-voltage slow transient evolving into generalized low-voltage fast activity, likely reflecting sustained fast neuronal firing over a wide cortical area. The typical interictal discharges (runs of slow spike-and-wave and bursts of generalized paroxysmal fast activity) also have a "generalized" electrical field, suggesting widespread cortical involvement. Recent brain mapping studies have begun to reveal which cortical and subcortical regions are active during these "generalized" discharges. In this critical review, we examine findings from neuroimaging studies of LGS and place these in the context of the electrical and clinical features of the syndrome. We suggest that LGS can be conceptualized as "secondary network epilepsy," where the epileptic activity is expressed through large-scale brain networks, particularly the attention and default-mode networks. Cortical lesions, when present, appear to chronically interact with these networks to produce network instability rather than triggering each individual epileptic discharge. LGS can be considered as "secondary" network epilepsy because the epileptic manifestations of the disorder reflect the networks being driven, rather than the specific initiating process. In this review, we begin with a summation of the clinical manifestations of LGS and what this has revealed about the underlying etiology of the condition. We then undertake a systematic review of the functional neuroimaging literature in LGS, which leads us to conclude that LGS can best be conceptualized as "secondary network epilepsy."
Internal ID Number: 25400619
URI: http://ahro.austin.org.au/austinjspui/handle/1/12477
DOI: 10.3389/fneur.2014.00225
URL: http://www.ncbi.nlm.nih.gov/pubmed/25400619
Type: Journal Article
Subjects: EEG–fMRI
Lennox–Gastaut syndrome
attention network
default-mode network
generalized epilepsy
paroxysmal fast activity
slow spike and wave
tonic seizure
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.