Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12466
Title: Response to MAPK pathway inhibitors in BRAF V600M-mutated metastatic melanoma.
Authors: Parakh, S;Murphy, C;Lau, D;Cebon, Jonathan S;Andrews, Miles C
Affiliation: Ludwig Institute for Cancer Research - Austin Branch, Heidelberg, Vic., Australia; Joint Austin-Ludwig Medical Oncology Unit, Austin Health, Heidelberg, Vic., Australia.
Issue Date: 10-Nov-2014
Citation: Journal of Clinical Pharmacy and Therapeutics 2014; 40(1): 121-3
Abstract: The management of metastatic melanoma has changed significantly in the past decade with the development of immunotherapies and targeted molecular therapies. Trials of targeted therapies have focused mainly on patients with the most common BRAF V600 mutations, namely V600E/K substitutions, with very little information available on the benefit of targeted therapies on less commonly occurring mutations such as V600R/D and M.We present a 54-year-old man with metastatic melanoma harbouring a rare BRAF V600M mutation, who experienced clinical and radiological response to combined therapy with the BRAF inhibitor dabrafenib and MEK inhibitor trametinib.As our understanding of these therapies evolves and an increasing number of patients have mutational testing performed, there is a clear imperative--as highlighted by this case--to test for rarer mutations and facilitate their inclusion both in everyday practice and in future clinical trials.
Internal ID Number: 25382067
URI: http://ahro.austin.org.au/austinjspui/handle/1/12466
DOI: 10.1111/jcpt.12229
URL: http://www.ncbi.nlm.nih.gov/pubmed/25382067
Type: Journal Article
Subjects: BRAF mutation
V600M
melanoma
targeted therapy
Appears in Collections:Journal articles

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