Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12465
Title: The failure of endothelin to displace bound, radioactively-labelled, calcium antagonists (PN 200/110, D888 and diltiazem).
Authors: Gu, X H;Liu, J J;Dillon, J S;Nayler, W G
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria.
Issue Date: 1-Feb-1989
Citation: British Journal of Pharmacology; 96(2): 262-4
Abstract: The effect of endothelin, a potent vasoconstrictor polypeptide, on three types of calcium antagonist binding sites was examined, in rat cardiac membrane fragments. Endothelin 10 nM affected neither the affinity nor density of dihydropyridine binding sites. At concentrations of 10(-12)-10(-7) M, endothelin failed to displace bound (+)-[3H]-PN 200/110, (-)-[3H]-D888 and (+)-cis-[3H]-diltiazem. These results suggest that the calcium antagonist binding sites associated with L-type calcium channels are not the primary site of action of endothelin.
Internal ID Number: 2538185
URI: http://ahro.austin.org.au/austinjspui/handle/1/12465
URL: http://www.ncbi.nlm.nih.gov/pubmed/2538185
Type: Journal Article
Subjects: Animals
Binding, Competitive
Calcium Channel Blockers.metabolism
Calcium Channels
Diltiazem.metabolism
Endothelins
Female
In Vitro Techniques
Isradipine
Oxadiazoles.metabolism
Peptides.metabolism.pharmacology
Rats
Rats, Inbred Strains
Receptors, Nicotinic.drug effects
Verapamil.analogs & derivatives.metabolism
Appears in Collections:Journal articles

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