Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12456
Title: Effects of the NMDA receptor antagonist MK-801 against amygdaloid-kindled seizures in the rat.
Authors: Young, N A;Lewis, S J;Vajda, F J;Beart, P M
Affiliation: University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Feb-1989
Citation: Experimental Neurology; 103(2): 199-202
Abstract: The effects of acute and subchronic administration of the noncompetitive NMDA receptor antagonist MK-801 on the duration and severity of amygdaloid-kindled seizures in rats were determined to evaluate its anticonvulsant activity. Both the highest acute (1000 micrograms/kg) and subchronic regimens (2 x 300 micrograms/kg, 7 days) produced significant reductions in the seizure stage and afterdischarge duration. Although ataxia may have affected the seizure stage, MK-801 attenuated the primary afterdischarge suggesting anticonvulsant effects in the fully amygdaloid-kindled rat. Since tolerance develops to the behavioral effects of MK-801, other noncompetitive NMDA antagonists related to MK-801 seem to warrant evaluation as anticonvulsants.
Internal ID Number: 2536332
URI: http://ahro.austin.org.au/austinjspui/handle/1/12456
URL: http://www.ncbi.nlm.nih.gov/pubmed/2536332
Type: Journal Article
Subjects: Amygdala.drug effects.physiology.physiopathology
Animals
Anticonvulsants.pharmacology
Dibenzocycloheptenes.pharmacology
Dizocilpine Maleate
Dose-Response Relationship, Drug
Kindling, Neurologic.drug effects
Male
Rats
Rats, Inbred Strains
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter.drug effects.physiology
Reference Values
Seizures.physiopathology
Appears in Collections:Journal articles

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