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|Title:||Effects of the NMDA receptor antagonist MK-801 against amygdaloid-kindled seizures in the rat.|
|Authors:||Young, N A;Lewis, S J;Vajda, F J;Beart, P M|
|Affiliation:||University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.|
|Citation:||Experimental Neurology; 103(2): 199-202|
|Abstract:||The effects of acute and subchronic administration of the noncompetitive NMDA receptor antagonist MK-801 on the duration and severity of amygdaloid-kindled seizures in rats were determined to evaluate its anticonvulsant activity. Both the highest acute (1000 micrograms/kg) and subchronic regimens (2 x 300 micrograms/kg, 7 days) produced significant reductions in the seizure stage and afterdischarge duration. Although ataxia may have affected the seizure stage, MK-801 attenuated the primary afterdischarge suggesting anticonvulsant effects in the fully amygdaloid-kindled rat. Since tolerance develops to the behavioral effects of MK-801, other noncompetitive NMDA antagonists related to MK-801 seem to warrant evaluation as anticonvulsants.|
|Internal ID Number:||2536332|
Dose-Response Relationship, Drug
Kindling, Neurologic.drug effects
Rats, Inbred Strains
Receptors, Neurotransmitter.drug effects.physiology
|Appears in Collections:||Journal articles|
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