Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12426
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dc.contributor.authorGao, Yuanen
dc.contributor.authorChurilov, Leoniden
dc.contributor.authorTeo, Sarahen
dc.contributor.authorYan, Bernarden
dc.date.accessioned2015-05-16T02:07:26Z
dc.date.available2015-05-16T02:07:26Z
dc.date.issued2014-10-07en
dc.identifier.citationJournal of Clinical Neuroscience 2014; 22(2): 352-6en
dc.identifier.govdoc25304437en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12426en
dc.description.abstractRemote intracerebral haemorrhage (rICH) is defined as intracerebral haemorrhage (ICH) post thrombolysis in brain regions without visible ischaemic changes. There is uncertainty that clinical outcomes and risk factors for rICH are different to those for local ICH. We investigated the morbidity, mortality and factors associated with rICH. We hypothesised that a previous history of cerebral ischaemic events is associated with increased risk of rICH. We included consecutive acute ischaemic stroke patients from 2003 to 2012 who were treated with intravenous thrombolysis. Clinical data included demographics, stroke classification, vascular risk factors and laboratory results. Clinical outcome was defined by modified Rankin Scale (mRS) score at 3 months. Baseline and follow-up CT scans were analysed for all ICH, and further dichotomised to rICH and local ICH. Clinical outcomes between rICH and local ICH were compared after adjustment for confounding factors. Four hundred and two patients were included in the study. The median age was 71 (interquartile range 60-79)years, and 54% were male. ICH (local ICH and rICH) was detected in 21.6% (87/402) of all patients post thrombolysis. The incidence of rICH was 2.2% (9/402). Most rICH were classified as haemorrhagic infarct category 2 (HI2) (p = 0.002). The proportion of patients with previous transient ischaemic attacks was significantly higher in the rICH group (33.33% versus 2.56%; odds ratio [OR] 18.75, 95% confidence interval [CI] 3.06-114.38; p = 0.007). The proportion of mRS scores 0-2 at 3 months was significantly higher in the rICH group (50% versus 28%; adjusted OR 10.469, 95%CI 1.474-74.338; p = 0.019). The 3 month mortality rate was 22.2% (2/9) in the rICH group and 36% (27/75) in the local ICH group (OR 0.53, 95%CI 0-2.51, p = 0.703). rICH was an infrequent complication after intravenous thrombolysis in our series. The clinical outcome of rICH was significantly better than local ICH. Of note, previous episodes of transient ischaemic attack were significantly higher in the rICH group, suggesting previous ischaemic injury as an underlying mechanism.en
dc.language.isoenen
dc.subject.otherIntracerebral haemorrhageen
dc.subject.otherIntravenous thrombolysisen
dc.subject.otherModified Rankin Scaleen
dc.subject.otherPrevious ischaemic attacken
dc.subject.otherrICHen
dc.subject.othertPAen
dc.titleRemote intracerebral haemorrhage post intravenous thrombolysis: experience from an Australian stroke centre.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Clinical Neuroscienceen
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationMelbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Grattan Street, Parkville, VIC 3050, Australiaen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.doi10.1016/j.jocn.2014.07.009en
dc.description.pages352-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25304437en
dc.type.austinJournal Articleen
local.name.researcherChurilov, Leonid
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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