Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12392
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dc.contributor.authorPhillips, P Aen
dc.contributor.authorSasadeus, Jen
dc.contributor.authorHodsman, G Pen
dc.contributor.authorHorowitz, J Den
dc.contributor.authorSaltups, Aen
dc.contributor.authorJohnston, Colin Ien
dc.date.accessioned2015-05-16T02:05:10Z
dc.date.available2015-05-16T02:05:10Z
dc.date.issued1989-02-01en
dc.identifier.citationBritish Heart Journal; 61(2): 139-43en
dc.identifier.govdoc2522310en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12392en
dc.description.abstractPlasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM] were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase.en
dc.language.isoenen
dc.subject.otherAngina Pectoris.blooden
dc.subject.otherAtrial Natriuretic Factor.blooden
dc.subject.otherChest Pain.blooden
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMyocardial Infarction.blood.drug therapyen
dc.subject.otherStreptokinase.therapeutic useen
dc.titlePlasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase.en
dc.typeJournal Articleen
dc.identifier.journaltitleBritish heart journalen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages139-43en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2522310en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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