Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12340
Title: Amyloid-β related memory decline is not associated with subjective or informant rated cognitive impairment in healthy adults.
Authors: Hollands, Simone;Lim, Yen Ying;Buckley, Rachel F;Pietrzak, Robert H;Snyder, Peter J;Ames, David;Ellis, Kathryn A;Harrington, Karra;Lautenschlager, Nicola T;Martins, Ralph N;Masters, Colin L;Villemagne, Victor L;Rowe, Christopher C;Maruff, Paul
Affiliation: Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia Cogstate Ltd., Melbourne, VIC, Australia
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, VIC, Australia School of Psychiatry and Clinical Neurosciences and Western Australian Centre for Health and Aging, University of Western Australia, Perth, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia Department of Neurology, Warren Alpert School of Medicine of Brown University & Lifespan Hospital System, Providence, RI, USA
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, VIC, Australia National Ageing Research Institute, Parkville, VIC, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia School of Psychology, University of Melbourne, Parkville, VIC, Australia
School of Psychology, Royal Melbourne Institute of Technology, Bundoora, VIC, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, VIC, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, Western Australia, Australia
Department of Neurology, Warren Alpert School of Medicine of Brown University & Lifespan Hospital System, Providence, RI, USA
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, VIC, Australia
Issue Date: 2015
Citation: Journal of Alzheimer's Disease : Jad; 43(2): 677-86
Abstract: The detection of early Alzheimer's disease (AD) can rely on subjective and informant reports of cognitive impairment. However, relationships between subjective cognitive impairment, objectively measured cognitive function, and amyloid-β (Aβ) biomarkers remain unclear.To determine the extent to which impairment or decline in subjective and informant rated cognitive impairment was associated with memory in healthy older adults with high Aβ.Healthy older adults (n = 289) enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study were studied at baseline. Pittsburgh Compound B was used to determine Aβ status at baseline. At baseline and 18 months assessments, subjective memory impairment was assessed using the Memory Complaint Questionnaire and the Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly. Cognition was measured using the Cogstate Brief Battery.At baseline, there were no differences between low and high Aβ groups in subjective or informant-rated cognitive impairment, depressive and anxiety symptoms, or cognitive function. Longitudinal analyses showed moderate decline in learning and working memory over the 18 months in the high Aβ group. However there was no change over time in subjective or informant-rated cognitive impairment, depressive and anxiety symptoms, or cognition in either Aβ group.Although healthy older adults with high Aβ levels show decline in learning and working memory over 18 months, subjective or informant ratings of cognitive impairment do not change over the same period suggesting subjective cognitive impairment may have limited utility for the very early identification of AD.
Internal ID Number: 25114076
URI: http://ahro.austin.org.au/austinjspui/handle/1/12340
DOI: 10.3233/JAD-140678
URL: http://www.ncbi.nlm.nih.gov/pubmed/25114076
Type: Journal Article
Subjects: Amyloid
cognitive
depression
subjective memory impairment
Appears in Collections:Journal articles

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