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|Title:||Improved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification.|
|Authors:||Ackermann, Uwe;Plougastel, Lucie;Goh, Yit Wooi;Yeoh, Shinn Dee;Scott, Andrew M|
|Affiliation:||Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; Ludwig Institute for Cancer Research, Melbourne Branch, VIC, Australia.|
Ecole National Supérior de Chimie de Rennes, Rennes, France.
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia.
|Citation:||Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine 2014; 94(): 72-6|
|Abstract:||The synthesis of [(18)F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to form [(18)F]FLETT was performed using an iPhase FlexLab module. The implementation of a vacuum distillation method afforded [(18)F]2-fluoroethyl azide in 87±5.3% radiochemical yield. The use of Cu(CH3CN)4PF6 and TBTA as catalyst enabled us to fully automate the [(18)F]FLETT synthesis without the need for the operator to enter the radiation field. [(18)F]FLETT was produced in higher overall yield (41.3±6.5%) and shorter synthesis time (67min) than with our previously reported manual method (32.5±2.5% in 130min).|
|Internal ID Number:||25113535|
|Appears in Collections:||Journal articles|
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