Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12339
Title: Improved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification.
Authors: Ackermann, Uwe;Plougastel, Lucie;Goh, Yit Wooi;Yeoh, Shinn Dee;Scott, Andrew M
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia; Ludwig Institute for Cancer Research, Melbourne Branch, VIC, Australia.
Ecole National Supérior de Chimie de Rennes, Rennes, France.
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, VIC, Australia; The University of Melbourne, Parkville, VIC, Australia.
Issue Date: 24-Jul-2014
Citation: Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine 2014; 94(): 72-6
Abstract: The synthesis of [(18)F]2-fluoroethyl azide and its subsequent click reaction with 5-ethynyl-2'-deoxyuridine (EDU) to form [(18)F]FLETT was performed using an iPhase FlexLab module. The implementation of a vacuum distillation method afforded [(18)F]2-fluoroethyl azide in 87±5.3% radiochemical yield. The use of Cu(CH3CN)4PF6 and TBTA as catalyst enabled us to fully automate the [(18)F]FLETT synthesis without the need for the operator to enter the radiation field. [(18)F]FLETT was produced in higher overall yield (41.3±6.5%) and shorter synthesis time (67min) than with our previously reported manual method (32.5±2.5% in 130min).
Internal ID Number: 25113535
URI: http://ahro.austin.org.au/austinjspui/handle/1/12339
DOI: 10.1016/j.apradiso.2014.07.009
URL: http://www.ncbi.nlm.nih.gov/pubmed/25113535
Type: Journal Article
Subjects: Automation
Click chemistry
Fluorine-18
Vacuum distillation
Appears in Collections:Journal articles

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