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Title: Ethanol versus heparin locks for the prevention of central venous catheter-associated bloodstream infections: a randomized trial in adult haematology patients with Hickman devices.
Authors: Worth, Leon J;Slavin, M A;Heath, S;Szer, J;Grigg, Andrew P
Affiliation: Department of Infectious Diseases and Infection Prevention, Peter MacCallum Cancer Centre, Australia. Electronic address:
Department of Infectious Diseases and Infection Prevention, Peter MacCallum Cancer Centre, Australia; Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Department of Clinical Haematology and Bone Marrow Transplant Service, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.
Haematology Department, Austin Health, Heidelberg, Victoria, Australia.
Issue Date: 2-Jul-2014
Citation: The Journal of Hospital Infection 2014; 88(1): 48-51
Abstract: The effectiveness of ethanol locks for prevention of central venous catheter (CVC)-associated bloodstream infection (CLABSI) in adult haematology patients has not been thoroughly evaluated. This study aimed to compare prospectively heparinized saline with 70% ethanol locks using 2 h dwell time in patients with tunnelled CVCs. In saline (N = 43) and ethanol (N = 42) groups, CLABSI rates were 6.0 [95% confidence interval (CI): 3.4-9.8] and 4.1 (95% CI: 1.9-7.7) per 1000 CVC days, respectively (P = 0.42). In the ethanol group, two exit-site infections and one tunnel/pocket infection were observed. Reduction in device-associated infection was not achieved with prophylactic 70% ethanol locks in patients with haematological malignancy and tunnelled CVCs.
Internal ID Number: 25063013
DOI: 10.1016/j.jhin.2014.06.007
Type: Journal Article
Subjects: Bloodstream infection
Bone marrow transplantation
Central venous catheter
Ethanol lock
Catheter-Related Infections.prevention & control
Central Venous Catheters.microbiology
Hematologic Neoplasms.complications
Middle Aged
Prospective Studies
Sepsis.prevention & control
Treatment Outcome
Young Adult
Appears in Collections:Journal articles

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