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Title: Immune consequences of kinase inhibitors in development, undergoing clinical trials and in current use in melanoma treatment.
Authors: Vella, Laura J;Andrews, Miles C;Behren, Andreas;Cebon, Jonathan S;Woods, Katherine
Affiliation: Ludwig Institute for Cancer Research, Melbourne-Austin Branch, Cancer Immuno-biology Laboratory, Heidelberg, VIC 3084, Australia
Issue Date: 17-Jun-2014
Citation: Expert Review of Clinical Immunology 2014; 10(8): 1107-23
Abstract: Metastatic malignant melanoma is a frequently fatal cancer. In recent years substantial therapeutic progress has occurred with the development of targeted kinase inhibitors and immunotherapeutics. Targeted therapies often result in rapid clinical benefit however responses are seldom durable. Immune therapies can result in durable disease control but responses may not be immediate. Optimal cancer therapy requires both rapid and durable cancer control and this can likely best be achieved by combining targeted therapies with immunotherapeutics. To achieve this, a detailed understanding of the immune consequences of the various kinase inhibitors, in development, clinical trial and currently used to treat melanoma is required.
Internal ID Number: 24939732
DOI: 10.1586/1744666X.2014.929943
Type: Journal Article
Subjects: MAPK
combination therapy
kinase inhibition
Clinical Trials as Topic
Drug Discovery
Molecular Targeted Therapy
Neoplasm Metastasis
Protein Kinase Inhibitors.therapeutic use
Signal Transduction.drug effects
Skin Neoplasms.immunology.therapy
Appears in Collections:Journal articles

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