Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12260
Title: In vivo tau imaging: obstacles and progress.
Authors: Villemagne, Victor L;Okamura, Nobuyuki
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, VIC, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia. Electronic address: victorlv@unimelb.edu.au.
Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Issue Date: 1-Jun-2014
Citation: Alzheimer's & Dementia : the Journal of the Alzheimer's Association; 10(3 Suppl): S254-64
Abstract: The military conflicts of the last decade have highlighted the growing problem of traumatic brain injury in combatants returning from the battlefield. The considerable evidence pointing at the accumulation of tau aggregates and its recognition as a risk factor in neurodegenerative conditions such as Alzheimer's disease have led to a major effort to develop selective tau ligands that would allow research into the physiopathologic underpinnings of traumatic brain injury and chronic traumatic encephalopathy in military personnel and the civilian population. These tracers will allow new insights into tau pathology in the human brain, facilitating research into causes, diagnosis, and treatment of traumatic encephalopathy and major neurodegenerative dementias, such as Alzheimer's disease and some variants of frontotemporal lobar degeneration, in which tau plays a role. The field of selective tau imaging has to overcome several obstacles, some of them associated with the idiosyncrasies of tau aggregation and others related to radiotracer design. A worldwide effort has focused on the development of imaging agents that will allow selective tau imaging in vivo. Recent progress in the development of these tracers is enabling the noninvasive assessment of the extent of tau pathology in the brain, eventually allowing the quantification of changes in tau pathology over time and its relation to cognitive performance, brain volumetrics, and other biomarkers, as well as assessment of efficacy and patient recruitment for antitau therapeutic trials.
Internal ID Number: 24924676
URI: http://ahro.austin.org.au/austinjspui/handle/1/12260
DOI: 10.1016/j.jalz.2014.04.013
URL: http://www.ncbi.nlm.nih.gov/pubmed/24924676
Type: Journal Article
Subjects: Alzheimer's disease
Chronic traumatic encephalopathy
Molecular neuroimaging
Neurodegeneration
Radiotracer design
Tau
Tauopathies
Animals
Brain.metabolism.radionuclide imaging
Humans
Neurodegenerative Diseases.metabolism.radionuclide imaging
Radiopharmaceuticals.chemistry.diagnostic use
tau Proteins.metabolism
Appears in Collections:Journal articles

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